To find a therapeutic regimen to treat nonspecific urethritis (mucopurulent cervicitis) quickly and reduce cross infection. Method: There were 280 patients in our study. The first group we used Azithromycin, and the second group we used Azithromycin adding external application tetracycline. Patiens of the last group received Azithromycin, gatifloxacin adding external application tetracycline. Result: The effective rate of the first group, the second and the third group is 71%,82% and 94%. Conclusion: Using Azithromycin, gatifloxacin adding external application tetracycline is a good way to treat non-gonococcal urethritis (mucopurulent cervicitis). The course of treatment is short and therapeutic efficacy is satisfactory.
Non-gonococcal urethritis (nongonococcal urethritis,NGU) primarily means the Chlamydia trachomatis or/(and) Mycoplasma (including Mycoplasma, ureaplasma, Mycoplasma and genital Mycoplasma hominis) caused by genito-urinary tract inflammation. Women’s chlamydia and Mycoplasma infections, mainly for cervicitis, reproductive tract inflammation. We use 3 different methods for the treatment of non-gonococcal urethritis (Mucopurulent cervicitis) and observation of its curative effect to explore a better treatment methods.
1 data and methods
1. 1 source and group: January 2004 to December 2006 to clinic patients in our hospital, leucorrhea, vulvar itching, urinary tract stimulate increased symptoms occur or sterility, vaginal secretions and cultivation of ureaplasma urealyticum and Mycoplasma hominis and Chlamydia trachomatis-positive patients in the study. Candida and excluded, and NG, trichomonal infection of patients and the ester macrolide or quinolone drug allergy patients. 280 cases of total, randomly divided into 3 groups. 3 set of cases by age, pathogens and pathogenesis-no significant statistical differences. As shown in table 1. Observation on the treatment of 1 patient symptoms, signs, and after a course of pathogen in vaginal secretion to check.
1.2 treatment method: first group alone Archie mold pigment (large ring within ester class, United States fai Swiss company) 1.0 qdx6d; second group with Archie mold pigment 1.0 qdx6d, plus with tetracycline (four ring pigment class, Guangdong Southland drug industry limited) 0.5 QD into vaginal 5~7d; third group with Archie mold pigment 1.0 qdx6d, plus for the Sha Xing (praziquantel Connaught ketone class, Chengdu business drug industry company) 0.4 qdx6d, four ring pigment 0.5 plug into vaginal QD 5~7d. At the same time ask the pause and to request the partners of life in patients with treatment.
Table 1 groups of pathogen in patients with Constitution (omitted)
1.3 clinical criteria: patient symptoms disappear, checks negative for the pathogens to cure; illness marked improvement, negative for the pathogens Excellent; condition unchanged or increased pathogen-positive people as invalid; total effective rate, and of the former two.
1.4 statistics: statistics using SPSS 13 software, comparison of efficiency between various groups of X2 examination.
2. 1 therapy: the first group (Group of azithromycin) effective rate of 71%, the second group (azithromycin + tetracycline group) the effective rate of 82%, the third group (azithromycin gatifloxacin + group + tetracycline) effective rate of 94%. Comparison of efficiency between various groups, both statistically significant differences (P<0.05). Total of 5 cases of patients during treatment continues living, treatment failure. Third group of patients with urethral irritation of 2 groups to disappear earlier than before, 85% significantly reduce flu symptoms after the drug 2~3D.
2. 2 adverse reactions: the main adverse reactions include nausea. The first group 1, second group 1, group 2 appears, adding 1~2D after using vitamin B6 20mg TID, nausea in patients with symptoms disappear.
Female reproductive tract with non-gonococcal infection is the main pathogens of Chlamydia trachomatis and Mycoplasma (including Mycoplasma, ureaplasma, Mycoplasma and genital Mycoplasma hominis). In developed countries, the female reproductive tract with non-gonococcal infection has become a sexually transmitted disease in the first place. Chlamydia trachomatis is a special form of parasitic organisms mainly infected epithelial columnar and transitional, may contribute to cervical mucous membrane inflammation, endometritis, salpingitis, pelvic inflammatory disease, finally result in infertility, ectopic pregnancy, . Chlamydia trachomatis infection of infectious intensity, often in couple communication each other. Parasitism of Mycoplasma in female reproductive tract, lower when host immunity, local environmental change or merge other pathogens infection may appear under the effects of pain and symptoms such as abdominal pain, leucorrhea, vulvar itching and become opportunistic infections. Ureaplasma urealyticum is not only can cause genital infections such as vaginal, cervical, and miscarriages, sterility and fetal intrauterine growth retardation is closely [2,3]. So on the female reproductive tract with non-gonococcal infections should be actively treated.
Azithromycin to macrocyclic Lactone drug, semi-synthetic, through a combination with 50S Ribosome subunit and inhibits bacterial protein synthesis, their infection is the tissue concentration of blood concentration of dozens of times, efficient 80%~90%. For the treatment of non-gonococcal Genitourinary tract inflammation of one of the preferred drug. But some patients already in heavy use in the primary hospital, some cases of drug-resistant. Patients during the review, there are still increasing leucorrhea, vulvar itching, irritation of the urinary tract when, Yi-line drug susceptibility testing.
Tetracycline is a broad-spectrum antibiotic bacterial resistance to tetracycline drugs currently a higher percentage, so it is mainly used for rickettsia and chlamydia, Mycoplasma and other non-bacterial infections . The study on the use of tetracycline topical, avoiding such oral gastrointestinal drug reaction, increasing local drug concentration, reaching significant antimicrobial effect. Azithromycin combined with tetracycline group efficiency and azithromycin in the treatment group compared statistically significant differences.
Gatifloxacin is a third generation fluoroquinolone drugs, chlamydia and Mycoplasma treatment effect. This study of gatifloxacin combined with azithromycin in the treatment of nongonococcal Genitourinary tract inflammation, effect of satisfaction, urethral stimulation in patients with symptoms disappear significantly.
At the time of the treatment of nongonococcal Genitourinary tract inflammation, important is to ask the husband and wife while in treatment, a small number of patients do not know how to present the, Tongzhi without both sides, the treatment was not banned when sexual intercourse, so some cases treatment failure. At the time of the treatment of nongonococcal Genitourinary tract inflammation, request couple of Tongzhi, disinfection underwear after negative conversion in order to prevent recurrence and spread.
To sum up, azithromycin gatifloxacin + oral + tetracycline combined external application in the treatment of non-gonococcal Genitourinary tract inflammation, good curative effect, symptoms disappear quickly, is a simple and effective method of treatment.