To observe the clinical efficacy of “Golden bifid” on the treatment of premature with feeding intolerance. Method: 76 cases of premature with feeding intolerance were assigned into two groups by randomization:the therapeutic group contained 40 cases and the control group contained 36. Both group of infants were given the routine nursery and treatment, intravenous transfusion was given as well. Moreover, the infants of the therapeutic group were extra given the “Golden bifid” (A pill of tri-covalent viable organism from Inner Mongolian Shuang Qi drug company) by oral or nasal feeding, 0.5g a time, two times a day, and the period of treatment lasted for 5 days. Result: In the therapeutic group, 32 cases showed excellence (obviously effective), 7 cases showed utility (effective) and 1 case showed ineffective, the total effective rate is 97.5%. Among the control group, 8cases showed excellence (obviously effective), 18 cases showed utility (effective) and 10 cases showed ineffective, the total effective rate is 72.2%. After comparing the effective rate of both groups (by chi-square test),X2=7.84, P<0.01, the difference is of significance. Conclusion: The clinical efficacy of “golden bifid” on the treatment of premature with feeding intolerance has been proved certainly,without side effects yet.
Due to gastrointestinal function in preterm infants is extremely low, easy occurrence of abdominal distention, gastric retention, feeding intolerance manifestations such as vomiting, severe rebound effect body weight and survival rates. More and more studies show that early effective nutrition after birth may improve recent weight gain, reduce mortality in preterm infants, affecting long-term prognosis .
Golden Bifidobacterium bifidus is the long, Bulgaria consisting of Lactobacillus, Streptococcus thermophilus triple viable probiotics. Study on the use of Golden bifid in the treatment of feeding intolerance in preterm infants in 40 cases, focusing on the treatment of feeding intolerance in preterm infants, are reported below.
1 objects and methods
1. 1: January 2001 to October 2004 in preterm infants with neonatal inpatient hospital, select include abdominal distention, gastric retention, 76 cases of feeding intolerance manifestations such as vomiting. Where men and 45 cases, female, 31; gestational 28-30 weeks 4, 30-34 week 62, 34-36 10; weight <1500g 5, 1500~2000g62, >2000g9; age are in 3D. 76 cases of abdominal distension in 53 cases, gastric retention, 46 cases, vomiting in 15 cases, randomly divided into two groups, 40 cases of the treatment group, control group 36 cases. Two groups in small for gestational age, birth weight, age and the clinical manifestations are comparable (P>0.05). All cases are uncomplicated, acid-free drugs, antibiotics and other drugs affecting the effect of microecological and exclude organic disease of the digestive system surgery.
1. Method 2: two sets of cases are routine care and treatment, and parenteral nutrition support after treatment group breast Golden Bifidobacterium oral or nasogastric 0.5G,2/d, course 5d. Golden bifid for double odd pharmaceutical production in Inner Mongolia long containing Bifidobacterium, Bulgaria lactobacillus, Streptococcus thermophilus triple live bacteria.
1. 3 therapeutic efficiency: Excellent: abdominal distention, gastric retention, vomiting and other symptoms, signs, disappeared; valid: disappear vomiting, abdominal distention, gastric retention significantly improve; void: the above symptoms, signs, no apparent change.
1. 4 statistical methods: all statistics X2 examination.
1. 5 side effects: Probiotics Golden bifid in the treatment of feeding intolerance in preterm infants in 40 cases, did not see any adverse effects.
Excellent treatment group in 32 cases, effective 7, invalid 1 cases, total effective rate 97.5%, control group Excellent 8 cases, 18 cases effectively, invalid 10 cases, total effective rate 72.2%, comparing two groups efficient X2=7.84, р <0.01, differences are significant.
At present, still advocated the early feeding in preterm infants. Early on milk to prevent low blood glucose and hyperbilirubinemia, reduced protein itself dissolved, shorten the time of physiological weight loss and promote gastrointestinal maturation . However, poor digestion-absorption function of premature infants, early feeding prone to gastrointestinal disorders, abdominal distention, gastric retention, vomiting and other symptoms of feeding intolerance. Just was born of preterm infants gastric within PH value higher, in born 5~8d within pepsin is no activity of, duodenal of various protein enzyme activity also low, only digestive insufficient 80% of intake protein; newborn of fat digestive main through tongue fat enzyme and gastric fat enzyme, this II enzyme main role Yu in the chain glycerol three ester, not required bile salt, and long chain glycerol three ester of digestive depends on steapsin and bile salt Chylous particles of, preterm infants steapsin of activity lower, Cholic acid and bile salt of level also lower, on fat of digestive absorption ability limited; preterm infants because its pancreatic amylase level relative lower, its digestive carbohydrates of ability is limited of . And relying on gastrointestinal function in preterm infants with parenteral nutritional support a downside to promote early feeding tolerance, a longer length of stay requirements, economic disadvantages such as high. Therefore, you must look for effective methods of treatment, economy, easy.
Good can not survive without effective nutrition in premature infants, and this in turn depends on the digestion-absorption function of gastrointestinal tract, mucosal barrier function and power of a mature and perfect . Long Bifidobacterium, Bulgaria lactobacillus, Streptococcus thermophilus are the three important normal intestinal microflora, people from birth to death, has always maintained a harmonious symbiosis with them, their existence and amount of how much on human physiology and health have an important role. Through the add feeds directly, they can supplement the human normal bacterial Physiology, natural adjustments and maintain the ecological balance of intestinal flora, inhibiting intestinal fungus of potentially damaging to the human body. Among them, infant intestinal Bifidobacteria are predominant bacteria of the normal flora, its existence and on the number of how many infant physiological and health have an important impact on . In the process of digestion, absorption, excretion, Bifidobacterium, lactobacillus-oriented micro-ecological agent plays an increasingly important role.
Golden Bifidobacterium bifidus is the long, Bulgaria consisting of Lactobacillus, Streptococcus thermophilus triple viable probiotics, number of live high. Just was born of preterm infants, gastrointestinal road is no bacteria State, feeding in the application gold double dismutase can directly supplementary preterm infants intestinal within useful of physiological bacteria group, these physiological bacteria group contains various enzyme, can hydrolysed protein, decomposition carbohydrates, makes fat SOAP of, and dissolved cellulose, thus promote food of digestive, and absorption and using; metabolism process in the also produced large organic acid, stimulation wall Peristaltic, thus promote gastric of emptying.
Application of this article good effect of Golden bifid in the treatment of feeding intolerance in preterm infants, and shorten length of stay, lower case fatality rate, reduce the economic burden, be good treatment, and clinical application.
Result of feeding intolerance in preterm infants is a combination of factors, lower weight, gestational age as small as the higher the rate of feeding intolerance, particularly weight <2000g preterm infants. 76 cases of preterm infants with feeding intolerance in this article, of which there are 67 cases of weight <2000g, consistent with literature reports .